<?xml version="1.0" encoding="UTF-8"?> <sbml xmlns="http://www.sbml.org/sbml/level2" level="2" version="1"> <model id="small01_0" name="Synthetic Network: user specified input functions, and randomized parameters in generalized Hill Functions (nemo2sbml ver 1.6)"> <listOfUnitDefinitions> <unitDefinition id="volume" name="femtoliter"> <listOfUnits> <unit kind="litre" scale="-15" multiplier="1" offset="0"/> </listOfUnits> </unitDefinition> <unitDefinition id="microM_cell" name="microMole/cell"> <listOfUnits> <unit kind="mole" scale="-6" multiplier="1" offset="0"/> <unit kind="litre" exponent="-1" scale="-15" multiplier="1" offset="0"/> </listOfUnits> </unitDefinition> <unitDefinition id="hill_coeff" name="Hill Coefficient"> <listOfUnits> <unit kind="dimensionless" multiplier="1" offset="0"/> </listOfUnits> </unitDefinition> <unitDefinition id="s_fl" name="sec/femtoliter"> <listOfUnits> <unit kind="second" multiplier="1" offset="0"/> <unit kind="litre" exponent="-1" scale="-15" multiplier="1" offset="0"/> </listOfUnits> </unitDefinition> <unitDefinition id="s_mole" name="sec/microMole"> <listOfUnits> <unit kind="second" multiplier="1" offset="0"/> <unit kind="mole" exponent="-1" scale="-6" multiplier="1" offset="0"/> </listOfUnits> </unitDefinition> </listOfUnitDefinitions> <listOfCompartments> <compartment id="Cell" size="1"/> </listOfCompartments> <listOfSpecies> <species id="devNull" name="devNull" compartment="Cell" initialConcentration="0" boundaryCondition="true" constant="true"/> <species id="P5" name="P5" compartment="Cell" initialConcentration="1"/> <species id="P0" name="P0" compartment="Cell" initialConcentration="1"/> <species id="P1" name="P1" compartment="Cell" initialConcentration="1"/> <species id="P2" name="P2" compartment="Cell" initialConcentration="1"/> <species id="P3" name="P3" compartment="Cell" initialConcentration="1"/> <species id="P4" name="P4" compartment="Cell" initialConcentration="1"/> <species id="P6" name="P6" compartment="Cell" initialConcentration="1"/> <species id="P7" name="P7" compartment="Cell" initialConcentration="1"/> <species id="P8" name="P8" compartment="Cell" initialConcentration="1"/> <species id="P9" name="P9" compartment="Cell" initialConcentration="1"/> <species id="P10" name="P10" compartment="Cell" initialConcentration="1"/> </listOfSpecies> <listOfReactions> <reaction id="P0_synthesis" name="P0 synthesis" reversible="false"> <listOfReactants> <speciesReference species="devNull"/> </listOfReactants> <listOfProducts> <speciesReference species="P0"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="P5"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <divide/> <ci> B_0 </ci> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <power/> <apply> <divide/> <ci> P5 </ci> <ci> K_0 </ci> </apply> <ci> n_0 </ci> </apply> </apply> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="B_0" value="0.0255442166510387" units="microM_cell"/> <parameter id="K_0" value="0.599272008557943" units="microM_cell"/> <parameter id="n_0" value="2" units="hill_coeff"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P0_degrad" name="P0 degradation" reversible="false"> <listOfReactants> <speciesReference species="P0"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <times/> <ci> dc_0 </ci> <ci> P0 </ci> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="dc_0" value="0.0152468466878967" units="dimensionless"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P0_differenceEquationTerm" name="P0 differenceEquationTerm" reversible="false"> <listOfReactants> <speciesReference species="P0"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <ci> P0 </ci> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P1_synthesis" name="P1 synthesis" reversible="false"> <listOfReactants> <speciesReference species="devNull"/> </listOfReactants> <listOfProducts> <speciesReference species="P1"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="P0"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <divide/> <apply> <times/> <ci> B_1 </ci> <apply> <power/> <apply> <divide/> <ci> P0 </ci> <ci> K_1 </ci> </apply> <ci> n_1 </ci> </apply> </apply> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <power/> <apply> <divide/> <ci> P0 </ci> <ci> K_1 </ci> </apply> <ci> n_1 </ci> </apply> </apply> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="B_1" value="0.821302297447584" units="microM_cell"/> <parameter id="K_1" value="1.06049318532163" units="microM_cell"/> <parameter id="n_1" value="1" units="hill_coeff"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P1_degrad" name="P1 degradation" reversible="false"> <listOfReactants> <speciesReference species="P1"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <times/> <ci> dc_1 </ci> <ci> P1 </ci> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="dc_1" value="0.0427740170655563" units="dimensionless"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P1_differenceEquationTerm" name="P1 differenceEquationTerm" reversible="false"> <listOfReactants> <speciesReference species="P1"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <ci> P1 </ci> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P2_synthesis" name="P2 synthesis" reversible="false"> <listOfReactants> <speciesReference species="devNull"/> </listOfReactants> <listOfProducts> <speciesReference species="P2"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="P1"/> <modifierSpeciesReference species="P0"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <divide/> <apply> <plus/> <ci> B_2 </ci> <ci> B_4 </ci> </apply> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <times/> <apply> <power/> <apply> <divide/> <ci> P1 </ci> <ci> K_2 </ci> </apply> <ci> n_2 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P0 </ci> <ci> K_3 </ci> </apply> <ci> n_3 </ci> </apply> </apply> <apply> <times/> <apply> <power/> <apply> <divide/> <ci> P0 </ci> <ci> K_4 </ci> </apply> <ci> n_4 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P1 </ci> <ci> K_5 </ci> </apply> <ci> n_5 </ci> </apply> </apply> </apply> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="B_2" value="0.652595601506189" units="microM_cell"/> <parameter id="K_2" value="0.74367371412681" units="microM_cell"/> <parameter id="n_2" value="4" units="hill_coeff"/> <parameter id="K_3" value="729.491140559516" units="microM_cell"/> <parameter id="n_3" value="2.57575287125134" units="hill_coeff"/> <parameter id="B_4" value="0.784928923017354" units="microM_cell"/> <parameter id="K_4" value="0.66517550530272" units="microM_cell"/> <parameter id="n_4" value="3" units="hill_coeff"/> <parameter id="K_5" value="14.4265347142275" units="microM_cell"/> <parameter id="n_5" value="3.23004590633809" units="hill_coeff"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P2_degrad" name="P2 degradation" reversible="false"> <listOfReactants> <speciesReference species="P2"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <times/> <ci> dc_2 </ci> <ci> P2 </ci> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="dc_2" value="0.0972757585477675" units="dimensionless"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P2_differenceEquationTerm" name="P2 differenceEquationTerm" reversible="false"> <listOfReactants> <speciesReference species="P2"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <ci> P2 </ci> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P3_synthesis" name="P3 synthesis" reversible="false"> <listOfReactants> <speciesReference species="devNull"/> </listOfReactants> <listOfProducts> <speciesReference species="P3"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="P1"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <divide/> <apply> <times/> <ci> B_6 </ci> <apply> <power/> <apply> <divide/> <ci> P1 </ci> <ci> K_6 </ci> </apply> <ci> n_6 </ci> </apply> </apply> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <power/> <apply> <divide/> <ci> P1 </ci> <ci> K_6 </ci> </apply> <ci> n_6 </ci> </apply> </apply> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="B_6" value="0.428400195673632" units="microM_cell"/> <parameter id="K_6" value="1.04293221985112" units="microM_cell"/> <parameter id="n_6" value="4" units="hill_coeff"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P3_degrad" name="P3 degradation" reversible="false"> <listOfReactants> <speciesReference species="P3"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <times/> <ci> dc_6 </ci> <ci> P3 </ci> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="dc_6" value="0.0203520441641201" units="dimensionless"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P3_differenceEquationTerm" name="P3 differenceEquationTerm" reversible="false"> <listOfReactants> <speciesReference species="P3"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <ci> P3 </ci> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P4_synthesis" name="P4 synthesis" reversible="false"> <listOfReactants> <speciesReference species="devNull"/> </listOfReactants> <listOfProducts> <speciesReference species="P4"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="P1"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <divide/> <apply> <times/> <ci> B_7 </ci> <apply> <power/> <apply> <divide/> <ci> P1 </ci> <ci> K_7 </ci> </apply> <ci> n_7 </ci> </apply> </apply> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <power/> <apply> <divide/> <ci> P1 </ci> <ci> K_7 </ci> </apply> <ci> n_7 </ci> </apply> </apply> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="B_7" value="0.452875226600554" units="microM_cell"/> <parameter id="K_7" value="1.23087790427809" units="microM_cell"/> <parameter id="n_7" value="2" units="hill_coeff"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P4_degrad" name="P4 degradation" reversible="false"> <listOfReactants> <speciesReference species="P4"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <times/> <ci> dc_7 </ci> <ci> P4 </ci> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="dc_7" value="0.0665835651225051" units="dimensionless"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P4_differenceEquationTerm" name="P4 differenceEquationTerm" reversible="false"> <listOfReactants> <speciesReference species="P4"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <ci> P4 </ci> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P5_synthesis" name="P5 synthesis" reversible="false"> <listOfReactants> <speciesReference species="devNull"/> </listOfReactants> <listOfProducts> <speciesReference species="P5"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="P1"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <divide/> <apply> <times/> <ci> B_8 </ci> <apply> <power/> <apply> <divide/> <ci> P1 </ci> <ci> K_8 </ci> </apply> <ci> n_8 </ci> </apply> </apply> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <power/> <apply> <divide/> <ci> P1 </ci> <ci> K_8 </ci> </apply> <ci> n_8 </ci> </apply> </apply> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="B_8" value="0.0252050087752454" units="microM_cell"/> <parameter id="K_8" value="0.603253401961709" units="microM_cell"/> <parameter id="n_8" value="3" units="hill_coeff"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P5_degrad" name="P5 degradation" reversible="false"> <listOfReactants> <speciesReference species="P5"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <times/> <ci> dc_8 </ci> <ci> P5 </ci> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="dc_8" value="0.083944699358757" units="dimensionless"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P5_differenceEquationTerm" name="P5 differenceEquationTerm" reversible="false"> <listOfReactants> <speciesReference species="P5"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <ci> P5 </ci> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P6_synthesis" name="P6 synthesis" reversible="false"> <listOfReactants> <speciesReference species="devNull"/> </listOfReactants> <listOfProducts> <speciesReference species="P6"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="P1"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <divide/> <apply> <times/> <ci> B_9 </ci> <apply> <power/> <apply> <divide/> <ci> P1 </ci> <ci> K_9 </ci> </apply> <ci> n_9 </ci> </apply> </apply> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <power/> <apply> <divide/> <ci> P1 </ci> <ci> K_9 </ci> </apply> <ci> n_9 </ci> </apply> </apply> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="B_9" value="0.0674994962168116" units="microM_cell"/> <parameter id="K_9" value="0.661110184765306" units="microM_cell"/> <parameter id="n_9" value="4" units="hill_coeff"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P6_degrad" name="P6 degradation" reversible="false"> <listOfReactants> <speciesReference species="P6"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <times/> <ci> dc_9 </ci> <ci> P6 </ci> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="dc_9" value="0.0847338999747789" units="dimensionless"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P6_differenceEquationTerm" name="P6 differenceEquationTerm" reversible="false"> <listOfReactants> <speciesReference species="P6"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <ci> P6 </ci> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P7_synthesis" name="P7 synthesis" reversible="false"> <listOfReactants> <speciesReference species="devNull"/> </listOfReactants> <listOfProducts> <speciesReference species="P7"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="P3"/> <modifierSpeciesReference species="P4"/> <modifierSpeciesReference species="P5"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <divide/> <apply> <plus/> <apply> <times/> <ci> B_10 </ci> <apply> <power/> <apply> <divide/> <ci> P3 </ci> <ci> K_10 </ci> </apply> <ci> n_10 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P4 </ci> <ci> K_11 </ci> </apply> <ci> n_11 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P5 </ci> <ci> K_12 </ci> </apply> <ci> n_12 </ci> </apply> </apply> <ci> B_15 </ci> <apply> <times/> <ci> B_18 </ci> <apply> <power/> <apply> <divide/> <ci> P5 </ci> <ci> K_18 </ci> </apply> <ci> n_18 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P3 </ci> <ci> K_19 </ci> </apply> <ci> n_19 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P4 </ci> <ci> K_20 </ci> </apply> <ci> n_20 </ci> </apply> </apply> </apply> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <times/> <apply> <power/> <apply> <divide/> <ci> P3 </ci> <ci> K_10 </ci> </apply> <ci> n_10 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P4 </ci> <ci> K_13 </ci> </apply> <ci> n_13 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P5 </ci> <ci> K_14 </ci> </apply> <ci> n_14 </ci> </apply> </apply> <apply> <times/> <apply> <power/> <apply> <divide/> <ci> P4 </ci> <ci> K_15 </ci> </apply> <ci> n_15 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P3 </ci> <ci> K_16 </ci> </apply> <ci> n_16 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P5 </ci> <ci> K_17 </ci> </apply> <ci> n_17 </ci> </apply> </apply> <apply> <times/> <apply> <power/> <apply> <divide/> <ci> P5 </ci> <ci> K_18 </ci> </apply> <ci> n_18 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P3 </ci> <ci> K_21 </ci> </apply> <ci> n_21 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P4 </ci> <ci> K_22 </ci> </apply> <ci> n_22 </ci> </apply> </apply> </apply> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="B_10" value="0.133839862789941" units="microM_cell"/> <parameter id="K_10" value="0.621128382100423" units="microM_cell"/> <parameter id="n_10" value="2" units="hill_coeff"/> <parameter id="K_11" value="228.535977391391" units="microM_cell"/> <parameter id="n_11" value="2.53838621572808" units="hill_coeff"/> <parameter id="K_12" value="606.185346153917" units="microM_cell"/> <parameter id="n_12" value="1.18958291667229" units="hill_coeff"/> <parameter id="K_13" value="450.10545841558" units="microM_cell"/> <parameter id="n_13" value="2.3964026154114" units="hill_coeff"/> <parameter id="K_14" value="662.494380484228" units="microM_cell"/> <parameter id="n_14" value="2.38103339113848" units="hill_coeff"/> <parameter id="B_15" value="0.331491411577208" units="microM_cell"/> <parameter id="K_15" value="1.33829765946979" units="microM_cell"/> <parameter id="n_15" value="2" units="hill_coeff"/> <parameter id="K_16" value="942.294369894489" units="microM_cell"/> <parameter id="n_16" value="2.21042409902269" units="hill_coeff"/> <parameter id="K_17" value="320.577724264963" units="microM_cell"/> <parameter id="n_17" value="1.61827991841154" units="hill_coeff"/> <parameter id="B_18" value="0.539510469389875" units="microM_cell"/> <parameter id="K_18" value="0.989559961735971" units="microM_cell"/> <parameter id="n_18" value="4" units="hill_coeff"/> <parameter id="K_19" value="694.199975129971" units="microM_cell"/> <parameter id="n_19" value="0.876067222552703" units="hill_coeff"/> <parameter id="K_20" value="525.866214780253" units="microM_cell"/> <parameter id="n_20" value="4.05430051544036" units="hill_coeff"/> <parameter id="K_21" value="19.0463447408812" units="microM_cell"/> <parameter id="n_21" value="2.97750903175341" units="hill_coeff"/> <parameter id="K_22" value="66.4888102429183" units="microM_cell"/> <parameter id="n_22" value="3.85532196036749" units="hill_coeff"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P7_degrad" name="P7 degradation" reversible="false"> <listOfReactants> <speciesReference species="P7"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <times/> <ci> dc_10 </ci> <ci> P7 </ci> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="dc_10" value="0.0483040081450481" units="dimensionless"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P7_differenceEquationTerm" name="P7 differenceEquationTerm" reversible="false"> <listOfReactants> <speciesReference species="P7"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <ci> P7 </ci> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P8_synthesis" name="P8 synthesis" reversible="false"> <listOfReactants> <speciesReference species="devNull"/> </listOfReactants> <listOfProducts> <speciesReference species="P8"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="P4"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <divide/> <apply> <times/> <ci> B_23 </ci> <apply> <power/> <apply> <divide/> <ci> P4 </ci> <ci> K_23 </ci> </apply> <ci> n_23 </ci> </apply> </apply> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <power/> <apply> <divide/> <ci> P4 </ci> <ci> K_23 </ci> </apply> <ci> n_23 </ci> </apply> </apply> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="B_23" value="0.729714999337524" units="microM_cell"/> <parameter id="K_23" value="1.19769878521328" units="microM_cell"/> <parameter id="n_23" value="1" units="hill_coeff"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P8_degrad" name="P8 degradation" reversible="false"> <listOfReactants> <speciesReference species="P8"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <times/> <ci> dc_23 </ci> <ci> P8 </ci> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="dc_23" value="0.0191570316560791" units="dimensionless"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P8_differenceEquationTerm" name="P8 differenceEquationTerm" reversible="false"> <listOfReactants> <speciesReference species="P8"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <ci> P8 </ci> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P9_synthesis" name="P9 synthesis" reversible="false"> <listOfReactants> <speciesReference species="devNull"/> </listOfReactants> <listOfProducts> <speciesReference species="P9"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="P3"/> <modifierSpeciesReference species="P5"/> <modifierSpeciesReference species="P6"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <divide/> <apply> <plus/> <apply> <times/> <ci> B_24 </ci> <apply> <power/> <apply> <divide/> <ci> P3 </ci> <ci> K_24 </ci> </apply> <ci> n_24 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P5 </ci> <ci> K_25 </ci> </apply> <ci> n_25 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P6 </ci> <ci> K_26 </ci> </apply> <ci> n_26 </ci> </apply> </apply> <apply> <times/> <ci> B_29 </ci> <apply> <power/> <apply> <divide/> <ci> P5 </ci> <ci> K_29 </ci> </apply> <ci> n_29 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P3 </ci> <ci> K_30 </ci> </apply> <ci> n_30 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P6 </ci> <ci> K_31 </ci> </apply> <ci> n_31 </ci> </apply> </apply> <apply> <times/> <ci> B_34 </ci> <apply> <power/> <apply> <divide/> <ci> P6 </ci> <ci> K_34 </ci> </apply> <ci> n_34 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P3 </ci> <ci> K_35 </ci> </apply> <ci> n_35 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P5 </ci> <ci> K_36 </ci> </apply> <ci> n_36 </ci> </apply> </apply> </apply> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <times/> <apply> <power/> <apply> <divide/> <ci> P3 </ci> <ci> K_24 </ci> </apply> <ci> n_24 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P5 </ci> <ci> K_27 </ci> </apply> <ci> n_27 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P6 </ci> <ci> K_28 </ci> </apply> <ci> n_28 </ci> </apply> </apply> <apply> <times/> <apply> <power/> <apply> <divide/> <ci> P5 </ci> <ci> K_29 </ci> </apply> <ci> n_29 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P3 </ci> <ci> K_32 </ci> </apply> <ci> n_32 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P6 </ci> <ci> K_33 </ci> </apply> <ci> n_33 </ci> </apply> </apply> <apply> <times/> <apply> <power/> <apply> <divide/> <ci> P6 </ci> <ci> K_34 </ci> </apply> <ci> n_34 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P3 </ci> <ci> K_37 </ci> </apply> <ci> n_37 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P5 </ci> <ci> K_38 </ci> </apply> <ci> n_38 </ci> </apply> </apply> </apply> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="B_24" value="0.783905830538395" units="microM_cell"/> <parameter id="K_24" value="1.11000391200772" units="microM_cell"/> <parameter id="n_24" value="2" units="hill_coeff"/> <parameter id="K_25" value="89.6717858511474" units="microM_cell"/> <parameter id="n_25" value="1.74193037714519" units="hill_coeff"/> <parameter id="K_26" value="605.898585077286" units="microM_cell"/> <parameter id="n_26" value="1.21212198119988" units="hill_coeff"/> <parameter id="K_27" value="60.6808230148014" units="microM_cell"/> <parameter id="n_27" value="0.222795889256471" units="hill_coeff"/> <parameter id="K_28" value="327.125164047305" units="microM_cell"/> <parameter id="n_28" value="1.67461850653077" units="hill_coeff"/> <parameter id="B_29" value="0.100977101086809" units="microM_cell"/> <parameter id="K_29" value="0.82938034314402" units="microM_cell"/> <parameter id="n_29" value="3" units="hill_coeff"/> <parameter id="K_30" value="807.706602340586" units="microM_cell"/> <parameter id="n_30" value="1.1096578563869" units="hill_coeff"/> <parameter id="K_31" value="535.968462296913" units="microM_cell"/> <parameter id="n_31" value="1.96757967547891" units="hill_coeff"/> <parameter id="K_32" value="711.709697653758" units="microM_cell"/> <parameter id="n_32" value="1.07854895681289" units="hill_coeff"/> <parameter id="K_33" value="105.415829243731" units="microM_cell"/> <parameter id="n_33" value="3.37821769462094" units="hill_coeff"/> <parameter id="B_34" value="0.294164931814365" units="microM_cell"/> <parameter id="K_34" value="0.558366997955616" units="microM_cell"/> <parameter id="n_34" value="2" units="hill_coeff"/> <parameter id="K_35" value="136.293327997196" units="microM_cell"/> <parameter id="n_35" value="0.441893064564934" units="hill_coeff"/> <parameter id="K_36" value="299.37192484851" units="microM_cell"/> <parameter id="n_36" value="2.54211402235091" units="hill_coeff"/> <parameter id="K_37" value="60.1635810154187" units="microM_cell"/> <parameter id="n_37" value="2.95771554875958" units="hill_coeff"/> <parameter id="K_38" value="98.4186287561309" units="microM_cell"/> <parameter id="n_38" value="3.44693978418587" units="hill_coeff"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P9_degrad" name="P9 degradation" reversible="false"> <listOfReactants> <speciesReference species="P9"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <times/> <ci> dc_24 </ci> <ci> P9 </ci> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="dc_24" value="0.0642478250712733" units="dimensionless"/> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P9_differenceEquationTerm" name="P9 differenceEquationTerm" reversible="false"> <listOfReactants> <speciesReference species="P9"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <ci> P9 </ci> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P10_synthesis" name="P10 synthesis" reversible="false"> <listOfReactants> <speciesReference species="devNull"/> </listOfReactants> <listOfProducts> <speciesReference species="P10"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="P5"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <apply> <power/> <apply> <sin/> <ci> P5 </ci> </apply> <cn type="integer"> 2 </cn> </apply> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="tau" value="1" units="s_mole"/> </listOfParameters> </kineticLaw> </reaction> <reaction id="P10_differenceEquationTerm" name="P10 differenceEquationTerm" reversible="false"> <listOfReactants> <speciesReference species="P10"/> </listOfReactants> <listOfProducts> <speciesReference species="devNull"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <divide/> <ci> P10 </ci> <ci> tau </ci> </apply> </math> <listOfParameters> <parameter id="tau" value="1" units="s_fl"/> </listOfParameters> </kineticLaw> </reaction> </listOfReactions> </model> </sbml>